David Galas
Professor
 

Selected Publications

Muller, F., Clarkson, S. G. and Galas, D.,  "Sequence of a 3.18 kb Tandem Repeat of Xenopus laevis DNA
        containing 8 tRNA Genes,"  Nucleic Acids Res. 15:7191 (1987). 

Jakowec, M., Prentki, P., Chandler, M. and Galas, D.,  "Mutational Analysis of the Open Reading Frames of IS1:
        Proteins Required for Transposition,"  Genetics 120:47-55 (1988).

Galas, D. and Chandler, M.,  "Bacterial Insertion Sequences" (review) chapter 4 in Mobile DNA, pp. 109-162,
        American Society for Microbiology, Washington, D.C. (1989). 

Hemsley, A., Arnheim, N. and Galas, D. J.,  "A Simple Method for Site-directed Mutagenesis Using the Polymerase
        Chain Reaction,"  Nucleic Acids Res. 17:6545-6551 (1989). 

Zerbib, D., Chandler, M., Freund, E., Prentki, P. and Galas, D., "Functional Organization of the Ends of IS1: Specific
        Binding Site for an IS1-encoded Protein," The EMBO J.  9:456-463 (1990). 

Cui, X., Li, H., Goradia, T. M., Lange, K., Kazazian, H. H., Galas, D. J. and Arnheim, N.,  "Single Sperm Typing:
        Determination of Genetic Distance Between the G globin and Parathyroid hormone Loci,"  Proc. Natl. Acad. Sci.,
        USA 86:9389-9393 (1989).

Galas, D.,  "Transposable Genetic Elements: Agents of Complex Change," Prog. Clin. Biol. Res., 340A:135-144 (1990).

Branscomb, E. W., Slezak, T., Galas, D. J., Pae, R., Carrano, A. V. and Waterman, M. S.,  "Optimizing
        Restriction Fragment Fingerprinting Methods for Ordering Large Genomic Libraries," Genomics  8:351-366 (1990).

Zerbib, D., Prentki, P., Gamas, P., Freund, E., Galas, D.J., and Chandler, M., "Functional Organization of the Ends of
        IS1:  Specific Binding Site for an IS1-encoded Protein," Mol. Microbiol. 4(9):1477-1486  (1990). 

Zerbib, P., Polard, P., Escoubas, J. M., Galas, D.J., and Chandler, M., "The Regulatory Role of the IS1-encoded
        InsA Protein in Transposition," Mol. Microbiol.  4(3):471-477  (1990). 

Zerbib, D., Polard, P., Escoubas, J-M., Chandler, M. and Galas, D., "The Regulatory Role of the IS1-encoded InsA
        Protein in Transposition," Mol. Microbiol.  5(2):1477-1486 (1991) 

Escoubas, J. M., Prere, M. F., Fayet, O., Salvignol, I., Galas, D. J., Zerbib, D., and Chandler, M., "Translational
        Control of Transposition Activity of the Bacterial Insertion Sequence IS1," The EMBO J., 10:705-712, (1991). 

Collins, F., Galas, D. J., "A New Five-year Plan for the U. S. Human Genome Project,"  Science 262: 43-46  (1993). 

Galas, D. J., "Important Unanswered Questions Concerning Radiation Risk Estimates," Radiat. Res., 136:139-143,
        (1993). 

Betermier, M., Galas, D. J., "Interaction of Fis Protein with DNA: Bending and Specificity of Binding," Biochimie.,
       76:958-967, (1994). 

Levy-Lahad E., Wasco W., Poorkaj P., Ramano D., Oshima J., Pettingell W., Yu C., Jondro P., Schmidt S., Wang K.,
        Crowley A., Fu YH., Guenette S., Galas D., Nemens E., Wijsman E., Bird T., Schellenberg G., Tanzi R.,
        "Candidate Gene for the Chromosome 1 Familial Alzheimer's Disease Locus," Science 269:973-977  (1995). 

Sun F, Galas, D. J., "A Mathematical Analysis of In Vitro Molecular Selection-Amplification," J Mol. Biol.,
       258:650-660, (1996). 

Galas, D. J., "Novel Genes Novel Functions and New Drugs," Pharm. Forum  8:22-25 (1997). 

Galas, D. J., "New Genetic Tools: Their Roles in Drug Discovery and Development," Int'l J. of Pharm. Med. 12:13-18
        (1998). 

Teter,B.,Goodman,S.D.,Galas,D.J., "DNA Bending and Twisting Properties of Integration Host Factor
        Determined by DNA Cyclization," Plasmid, 43:73-84 (2000). 

Brunkow, M., Jeffery, E., Hjerrild, K., Paeper, B., Clark, L., Wilkinson, J.E., Galas, D., Ziegler, S., Ramsdell, F., 

“Disruption of a New Forkhead/Winged-Helix Protein, Scurfin, Results in the Rapidly Fatal Lymphoproliferative

Disorder of the Scurfy (sf) Mutant Mouse,” Nature Genetics, 27:68-73, (2001).

Brunkow, M., Gardner, J., Van Ness, J., Paeper, B., Kovacevich, B., Proll, S., Skonier, J., Zhao,

L., Sabo, P.J., Fu, Y., Alisch, R., Gillett, L., Colbert, T., Tacconi, P., Galas, D., Hamersma, H.,

Beighton, P., Mulligan, J., “Bone Dysplasia Sclerosteosis Results from Loss of the SOST Gene

Product, a Novel Cystine Knot-Containing Protein,” American Journal of Human Genetics,

68:577-589, (2001).

Strahling-Hampton, K. Proll, S., Paeper, B., Zhao, Lei, Charmley, P., Brown, A., Gardner, J., Galas, D.J., Schatzman,

 R., Beighton, P., Papapoulos, S., Hamersma, H., and Brunkow, M, “ A 52kb deletion in the SOST-MEOX1 intergenic

region on 17q12-q21 is associated with van Buchem’s disease in the Dutch population,” American Journal of Medical Genetics,

Jun 15: 110 (2): 144-152, (2002).

Dewey, T.G., Galas, D. J., “Dynamic Models of Gene Expression and Classification,” Functional and Integrative Genomics,

1:269-278, (2001).

Galas, D. J., Dewey, T.G.,  “Integration of New Technologies in the Future of the Biological Sciences,

Firepower in the Lab:  Advanced Automation in the Fight Against Biological Threat,” (eds.  Layne and Beugelsdijk)

Joseph Henry Press, Washington, D.C., pp. 227-242 (2001).

Galas, D.J., “Making Sense of the Sequence,” Science, 291:1257-60, (2001).

Galas, D.J., “The Invention of Footprinting”, Trends in Biochemical Sciences, 26:690-693, (2001).

Galas, D.J., “Against giants or windmills?  The struggle for the human genome.” Trends in Biochemical Sciences,

27:324-325, (2002).

National Research Council Steering Committee:  George L. Kenyon, David M. DeMarini, Elaine Fuchs, Galas, D. J.,

Jack F. Kirsch, Thomas S. Leyh (contributing author), Walter H. Moos, Gregory A. Petsko, Dagmar Ringe, Gerald M. Rubin,

and Laura C. Sheahan (Staff Director), “Defining the Mandate of Proteomics in the Post-Genomic Era:  Workshop Report,”

Molecular & Cellular Proteomics, 1:763-780, (2002).

Hood, L. and Galas, D.J., “The Digital Code of DNA,” Nature, 421:444-448, (2003)

Bhan, A., Galas, D. J. and Dewey, T.G., “A Duplication Growth Model of Gene Expression Networks,”

Bioinformatics, 18, 1486-1493 (2002)

Chung, F., Dewey, T.G., Lu Liang, and Galas, D. J., “Duplication Models and Biological Networks,”

Journal of Computational Biology   (in press, 2003).

Van Ness, J., Van Ness, L., Galas, D.J., “Isothermal Reactions for the Amplification of Oligonucleotides,”

PNAS, April 15, 100: 4504-4509 (2003).

Van Ness, J., Erwin, B., Galas, D.J., “Self-Amplifying Arrays,” Science, (Submitted, 2003)

Galas, David J., Riggs, Henry, “Global Science and U.S. Security,) Science, 300: 1847, (2003).

Patents

Compositions and Methods for Increasing Bone Mineralization, U.S. #09/449,218.  November 24, 1999.

Chromosome 1 Gene and Gene Products Related to Alzheimer’s Disease, U.S. Patent No. 6,468,791 B1;

October 22, 2002

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